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Home Research Microfluidics/Biomedical

Microfluidic Vias Enable Nested Bioarrays and Autoregulatory Devices in Newtonian Fluids

Research Area: Microfluidics/Biomedical Year: 2006
Type of Publication: Article Keywords: autoregulation, microelectromechanical devices, polydimethylsiloxane, array logic
Authors: Emil Kartalov; Chris Walker; C. R. Taylor; W. F. Anderson; Axel Scherer
Journal: Proceedings of the National Academy of Sciences Volume: 103
Number: 33 Pages: 12280-12284
Month: August
We report on a fundamental technological advance for multilayer polydimethylsiloxane (PDMS) microfluidics. Vertical passages (vias), connecting channels located in different layers, are fabricated monolithically, in parallel, by simple and easy means. The resulting 3D connectivity greatly expands the potential complexity of microfluidic architecture. We apply the vias to printing nested bioarrays and building autoregulatory devices. A current source is demonstrated, while a diode and a rectifier are derived; all are building blocks for analog circuitry in Newtonian fluids. We also describe microfluidic septa and their applications. Vias lay the foundation for a new generation of microfluidic devices.
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