Caltech Nanofabrication Group

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Home Research Microfluidics/Biomedical



FluidicsOur ability to fabricate devices on the scale of biological structures and processes opens up a new world of opportunities for interdisciplinary research and biomedical technology.  We are actively developing implantable glucose and ion sensors. These integrated devices contain all necessary power, sensor, and communications systems, and with dimensions around 100um, these represent a new era of personalized medicine, where instant diagnosis and individualized drug administration become possible with continuous blood monitoring. Additionally, these characteristics are ideal for in vivo neural probes, enabling long-term monitoring of complex neural circuits at greatly enhanced resolution, critical for minimizing the risks of neuro surgery while providing a deeper understanding of brain function.  We're also leveraging our expertise in designing microfluidic systems, electronic and optical sensors to develop low-cost, integrated PCR devices in order to provide widely available disease diagnostics to developing nations, targeting areas where proper facilities and trained personel might not otherwise be accessible.






  • Scherer, A. (2015). A multiplex PCR assay for the simultaneous detection of Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis”. Experimental and Molecular Pathology, 98(2), 214. [More] 
  • Rajagopal, A., Scherer, A., Homyk, A. & Kartalov, E. (2013). Supercolor Coding Methods for Large-Scale Multiplexing of Biochemical Assays. Analytical Chemistry, 85(16), 7629-7636. [More] 
  • Maltezos, G., Lee, J., Rajagopal, A., Scholten, K., Kartalov, E. & Scherer, A. (2011). Microfluidic Blood Filtration Device. Biomedical Microdevices, 13(1), 143-146. [More] 
  • Maltezos, G., Johnston, M., Taganov, K., Srichantaratsamee, C., Gorman, J., Baltimore, D. et al. (2010). Exploring the Limits of Ultrafast Polymerase Chain Reaction Using Liquid for Thermal Heat Exchange: A Proof of Principle. Applied Physics Letters, 97(26), 264101. [More] 
  • Maltezos, G., Chantratita, W., Gomez, A., Gomez, F., Kartalov, E. & Scherer, A. (2010). Portable Real-Time PCR for Rapid Viral Identification. IVD Technology, 16(7). [More] 
  • Lin, D. H., Taylor, C. R., Anderson, W. F., Scherer, A. & Kartalov, E. (2010). Internally Calibrated Quantification of VEGF in Human Plasma by Fluorescence Immunoassays in Disposable Elastomeric Microfluidic Devices.. Journal of Chromatography B, 878(2), 258-263. [More] 
  • Liu, J., Chen, Y., Taylor, C. R., Scherer, A. & Kartalov, E. (2009). Elastomeric Microfluidic Diode and Rectifier Work with Newtonian Fluids. Journal of Applied Physics, 106(11), 114311. [More] 
  • Kartalov, E., Lin, D. H., Lee, D. T., Anderson, W. F., Taylor, C. R. & Scherer, A. (2008). Internally Calibrated Quantification of Protein Analytes in Human Serum by Fluorescence Immunoassays in Disposable Elastomeric Microfluidic Devices. Electrophoresis, 29(24), 5010-5016. [More] 
  • Maltezos, G., Gomez, A., Zhong, J. F., Gomez, F. A. & Scherer, A. (2008). Microfluidic Polymerase Chain Reaction. Applied Physics Letters, 93(24), 243901. [More] 
  • Vyawahare, S., Sitaula, S., Martin, S., Adalian, D. & Scherer, A. (2008). Electronic Control of Elastomeric Microfluidic Circuits with Shape Memory Actuators. Lab on a Chip, 9(8), 1530-1535. [More] 
  • Zhong, J. F., Chen, Y., Marcus, J. S., Scherer, A., Quake, S. R., Taylor, C. R. et al. (2008). A Microfluidic Processor for Gene Expression Profiling of Single Human Embryonic Stem Cells. Lab on a Chip, 8(1), 68-74. [More] 
  • Kartalov, E., Maltezos, G., Anderson, W. F., Taylor, C. R. & Scherer, A. (2007). Electrical Microfluidic Pressure Gauge for Elastomer Microelectromechanical Systems. Journal of Applied Physics, 102(8), 084909. [More] 
  • Maltezos, G., Johnston, M. L., Maltezos, D. G. & Scherer, A. (2007). Replication of Three-Dimensional Valves from Printed Wax Molds. Sensors and Actuators A, 135(2), 620-624. [More] 
  • Kartalov, E., Scherer, A., Quake, S. R., Taylor, C. R. & Anderson, W. F. (2007). Experimentally Validated Quantitative Linear Model for the Device Physics of Elastomeric Microfluidic Valves. Journal of Applied Physics, 101(6), 064505. [More] 
  • Gross, P. G., Kartalov, E., Scherer, A. & Weiner, L. P. (2007). Applications of Microfluidics for Neuronal Studies. Journal of the Neurological Sciences, 252(2), 135-143. [More] 
  • Maltezos, G., Garcia, E., Hanrahan, G., Gomez, F. A., Vyawahare, S., van Dam, R. M. et al. (2007). Design and Fabrication of Chemically Robust Three-Dimensional Microfluidic Valves. Lab on a Chip, 7(9), 1209-1211. [More] 
  • Zhong, J. F., Maltezos, G., Sheriff, Z., Burke, K., Scherer, A., Taylor, C. R. et al. (2006). Microfluidic Systems for Studying Cell Migration Regulation. Letters in Drug Design and Discovery, 3(9), 636-639. [More] 
  • Maltezos, G., Rajagopal, A. & Scherer, A. (2006). Evaporative Cooling in Microfluidic Channels. Applied Physics Letters, 89(7), 074107. [More] 
  • Kartalov, E., Walker, C., Taylor, C. R., Anderson, W. F. & Scherer, A. (2006). Microfluidic Vias Enable Nested Bioarrays and Autoregulatory Devices in Newtonian Fluids. Proceedings of the National Academy of Sciences, 103(33), 12280-12284. [More] 
  • Kartalov, E., Anderson, W. F. & Scherer, A. (2006). The Analytical Approach to Polydimethylsiloxane Microfluidic Technology and its Biological Applications. Journal of Nanoscience and Nanotechnology, 6(8), 2265-2277. [More] 
  • Kartalov, E., Zhong, J. F., Scherer, A., Quake, S. R., Taylor, C. R. & Anderson, W. F. (2006). High-Throughput Multi-Antigen Microfluidic Fluorescence Immunoassays. BioTechniques, 40(1), 85-90. [More] 
  • Vyawahare, S., Craig, K. M. & Scherer, A. (2006). Patterning Lines by Capillary Flows. Nano Letters, 6(2), 271-276. [More] 
  • Maltezos, G., Johnston, M. L. & Scherer, A. (2005). Thermal Management in Microfluidics Using micro-Peltier Junctions. Applied Physics Letters, 87(15), 154105. [More] 
  • Adams, M., Johnston, M. L., Scherer, A. & Quake, S. R. (2005). Polydimethylsiloxane Based Microfluidic Diode. Journal of Micromechanics and Microengineering, 15(8), 1517-1521. [More] 
  • Reese, M. O., van Dam, R. M., Scherer, A. & Quake, S. R. (2003). Microfabricated Fountain Pens for High-Density DNA Arrays. Genome Research, 13, 2348-2352. [More] 
  • Adams, M., Enzelberger, M., Quake, S. R. & Scherer, A. (2003). Microfluidic Integration on Detector Arrays for Absorption and Fluorescence Micro-Spectrometers. Sensors and Actuators A, 104(1), 25-31. [More] 
  • Quake, S. R. & Scherer, A. (2000). From Micro- to Nanofabrication with Soft Materials. Science, 290(5496), 1536-1539. [More] 
  • Unger, M. A., Chou, H.-P., Thorsen, T., Scherer, A. & Quake, S. R. (2000). Monolithic Microfabricated Valves and Pumps by Multilayer Soft Lithography. Science, 288(5463), 113-116. [More] 
  • Fu, A. Y., Spence, C., Scherer, A., Arnold, F. H. & Quake, S. R. (1999). A Microfabricated Fluorescence-Activated Cell Sorter. Nature Biotechnology, 17, 1109-1111. [More] 
  • Chou, H.-P., Spence, C., Scherer, A. & Quake, S. R. (1999). A Microfabricated Device for Sizing and Sorting DNA Molecules. Proceedings of the National Academy of Sciences, 96(1), 11-13. [More] 


Administrative and Financial Contact

Kate Finigan
MC 200-36, Caltech
1200 E California Blvd
Pasadena, CA 91125

Office:  212 Sloan Annex
Phone:  626.395.4585
Fax: 626.577.8442